Seizoen 2000/2001
| Datum | Plaats | Attendance | Tegenstander | Score | Scorers |
| FA Premier League | |||||
| 20/08/00 | Home | 67477 | Newcastle United | 2-0 | Johnsen,Cole |
| 22/08/00 | Away | 22007 | Ipswich Town | 1-1 | Beckham |
| 26/08/00 | Away | 25998 | West Ham United | 2-2 | Beckham,Cole |
| 05/09/00 | Home | 67447 | Bradford City | 6-0 | Beckham,Cole,Sheringham(2),Fortune(2) |
| 09/09/00 | Home | 67503 | Sunderland | 3-0 | Scholes(2),Sheringham |
| 16/09/00 | Away | 38541 | Everton | 3-1 | Butt,Giggs,Solskjaer |
| 23/09/00 | Home | 67568 | Chelsea | 3-3 | Beckham,Scholes,Sheringham |
| 01/10/00 | Away | 38146 | Arsenal | 0-1 | - |
| 14/10/00 | Away | 22132 | Leicester City | 3-0 | Sheringham(2),Solskjaer |
| 21/10/00 | Home | 67525 | Leeds United | 3-0 | Yorke,Beckham,o.g. |
| 28/10/00 | Home | 67581 | Southampton | 5-0 | Sheringham(3),Cole(2) |
| 04/11/00 | Away | 21079 | Coventry City | 2-1 | Cole,Beckham |
| 11/11/00 | Home | 67576 | Middlesbrough | 2-1 | Butt,Sheringham |
| 18/11/00 | Away | 34429 | Manchester City | 1-0 | Beckham |
| 25/11/00 | Away | 32910 | Derby County | 3-0 | Sheringham,Butt,Yorke |
| 02/12/00 | Home | 67583 | Tottenham Hotspur | 2-0 | Scholes,Solskjaer |
| 09/12/00 | Away | 20043 | Charlton Athletic | 3-3 | Giggs,Solskjaer,Keane |
| 17/12/00 | Home | 67533 | Liverpool | 0-1 | - |
| 23/12/00 | Home | 67597 | Ipswich Town | 2-0 | Solskjaer(2) |
| 26/12/00 | Away | 40889 | Aston Villa | 1-0 | Solskjaer |
| 30/12/00 | Away | 52134 | Newcastle United | 1-1 | Beckham |
| 01/01/01 | Home | 67603 | West Ham United | 3-1 | Solskjaer,Yorke,o.g. |
| 13/01/01 | Away | 20551 | Bradford City | 3-0 | Sheringham,Giggs,Chadwick |
| 20/01/01 | Home | 67533 | Aston Villa | 2-0 | G.Neville,Sheringham |
| 31/01/01 | Away | 48260 | Sunderland | 1-0 | Cole |
| 03/02/01 | Home | 67528 | Everton | 1-0 | Cole |
| 10/02/01 | Away | 34690 | Chelsea | 1-1 | Cole |
| 25/02/01 | Home | 67535 | Arsenal | 6-1 | Yorke(3),Solskjaer,Keane,Sheringham |
| 03/03/01 | Away | 40055 | Leeds United | 1-1 | Chadwick |
| 17/03/01 | Home | 67516 | Leicester City | 2-0 | Silvestre,Solskjaer |
| 31/03/01 | Away | 44806 | Liverpool | 0-2 | - |
| 10/04/01 | Home | 67505 | Charlton Athletic | 2-1 | Cole,Solskjaer |
| 14/04/01 | Home | 67637 | Coventry City | 4-2 | Yorke(2),Giggs,Scholes |
| 13/05/01 | Away | 15246 | Southampton | 1-2 | Giggs |
| 21/04/01 | Home | 67535 | Manchester City | 1-1 | Sheringham |
| 28/04/01 | Away | 34417 | Middlesbrough | 2-0 | P.Neville,Beckham |
| 05/05/01 | Home | 67526 | Derby County | 0-1 | - |
| 19/05/01 | Away | 36072 | Tottenham Hotspur | 1-3 | Scholes |
| FA Charity Shield | |||||
| 13/08/00 | Wembley | 65148 | Chelsea | 0-2 | - |
| FA Cup | |||||
| 3de Ronde | |||||
| 07/01/01 | Away | 19178 | Fulham(D1) | 2-1 | Sheringham,Solskjaer |
| 4de Ronde | |||||
| 28/01/01 | Home | 67029 | West Ham United | 0-1 | - |
| Worthington (League) Cup | |||||
| 3de Ronde | |||||
| 31/10/00 | Away | 18871 | Watford(D1) | 3-0 | Solskjaer(2),Yorke |
| 4de Ronde | |||||
| 28/11/00 | Away | 47543 | Sunderland | 1-2 | Yorke |
| UEFA Champions League | |||||
| 1ste Ronde | |||||
| 13/09/00 | Home | 62749 | Anderlecht(Bel) | 5-1 | Cole(3),Sheringham,Irwin |
| 19/09/00 | Away | 48432 | Dynamo Kiev(Oek) | 0-0 | - |
| 26/09/00 | Away | 28000 | PSV Eindhoven(Hol) | 1-3 | Scholes |
| 18/10/00 | Home | 66313 | PSV Eindhoven(Hol) | 3-1 | Sheringham,Scholes,Yorke |
| 24/10/00 | Away | 27500 | Anderlecht(Bel) | 1-2 | Irwin |
| 08/11/00 | Home | 66776 | Dynamo Kiev(Oek) | 1-0 | Sheringham |
| 2de Ronde | |||||
| 21/11/00 | Home | 65024 | Panathinaikos(Gre) | 3-1 | Sheringham,Scholes(2) |
| 06/12/00 | Away | 16500 | Sturm Graz(Aut) | 2-0 | Scholes,Giggs |
| 14/02/01 | Away | 49451 | Valencia(Spa) | 0-0 | - |
| 20/02/01 | Home | 66715 | Valencia(Spa) | 1-1 | Cole |
| 07/03/01 | Away | 16000 | Panathinaikos(Gre) | 1-1 | Scholes |
| 13/03/01 | Home | 66404 | Sturm Graz(Aut) | 3-0 | Keane,Sheringham,Butt |
| Kwartfinale | |||||
| 03/04/01 | Home | 66584 | Bayern Munchen(Ger) | 0-1 | - |
| 18/04/01 | Away | 60000 | Bayern Munchen(Ger) | 1-2 | Giggs |